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Methane produced by archaea in the forestomach of ruminants is a key contributor to rising levels of greenhouse gases leading to climate change. Nanoparticles were functionalized with an archaeal virus lytic enzyme, PeiR, active against a range of rumen Methanobrevibacter species
Methane produced by archaea in the forestomach of ruminants is a key contributor to rising levels of greenhouse gases leading to climate change. Nanoparticles functionalized with the archaeal virus lytic enzyme, PeiR, were shown to alter the methanogen community and reduce methane emissions in rumen simulations.
Bacteriophage-derived enzymes can be applied as biocontrol agents to target specific foodborne pathogens. Listeria monocytogenes has a high mortality rate and remains a serious problem in the ready-to-eat food sector. Bioparticles displaying only the amidase domain of the phage endolysin were more effective at inhibiting growth under laboratory conditions.
Mycobacteria are a genus of Actinobacteria that include human pathogens such as Mycobacterium tuberculosis (TB). Active TB disease can spread by airborne transmission to healthcare workers and to their community. The HHMI SEA-PHAGES program has contributed to discovering bacteriophages that are able to infect M. megmatis MC2 155.
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